Protective effect of omega-3 fatty acids on diethylnitrosamine toxicity in rats


Atakisi O., Atakisi E., Ozcan A., Karapehlivan M., Kart A.

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol.17, no.4, pp.467-471, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 4
  • Publication Date: 2013
  • Journal Name: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.467-471
  • Keywords: Diethylnitrosamine, Omega-3 fatty acids, Nitric oxide, Rat, POLYUNSATURATED FATTY-ACIDS, NITRIC-OXIDE, FISH-OIL, OXIDANT/ANTIOXIDANT STATUS, N-NITROSODIETHYLAMINE, ENZYME-ACTIVITIES, SUPPLEMENTATION, ANTIOXIDANTS, DONORS, AGENTS
  • Gazi University Affiliated: No

Abstract

OBJECTIVES: In this study, it was aimed to investigate the effect of n-3 fatty acids (n-3 FA) on diethylnitrosamine (DEN) toxicity with respect to alterations including nitric oxide (NO) formation, uric acid level as well as some liver related enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in rats.