The Effects of Melatonin on Intestinal Adaptation in a Rat Model of Short Bowel Syndrome

Guclu M., Demirogullari B., BARUN S., Ozen I. O., Karakus S. C., POYRAZ A., ...Daha Fazla

EUROPEAN JOURNAL OF PEDIATRIC SURGERY, cilt.24, sa.2, ss.150-157, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1055/s-0033-1343081
  • Dergi Adı: EUROPEAN JOURNAL OF PEDIATRIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.150-157
  • Anahtar Kelimeler: apoptosis, intestinal adaptation, melatonin, short bowel syndrome, GASTROINTESTINAL-TRACT, PARENTERAL-NUTRITION, FUNCTIONAL-CHANGES, RESECTION, GROWTH, MECHANISMS, TRYPTOPHAN, CHILDREN, LOCALIZATION, PHYSIOLOGY
  • Gazi Üniversitesi Adresli: Evet

Özet

Introduction Short bowel syndrome (SBS) is a clinical condition resulting from the loss of absorptive surface area following resection of 50% or more small bowel. Morphological and functional changes called "intestinal adaptation" occur in the residual intestine. Melatonin exists in the gastrointestinal tract and has effect on mitotic activity. Therefore, we hypothesized that melatonin may have beneficial effects on intestinal adaptation.