The effect of CYP2C9 and VKORC1 genetic polymorphisms on warfarin dose requirements in a pediatric population


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Taskin B. D. , KULA S., ERGÜN M. A. , Altun D., Olgunturk R., TUNAOĞLU F. S. , ...More

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.16, no.10, pp.791-796, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 10
  • Publication Date: 2016
  • Doi Number: 10.14744/anatoljcardiol.2015.6150
  • Journal Name: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.791-796
  • Keywords: CYP2C9, genetic polymorphism, INR, pharmacogenetics, VKORC1, warfarin, PATIENT CHARACTERISTICS, TURKISH POPULATION, IMPACT, FREQUENCY, GENOTYPES, VARIANTS

Abstract

Objective: The aim was to investigate the frequency of genetic polymorphisms of cytochrome P4502C9 (CYP2C9) and vitamin K epoxide reductase complex subunit1 (VKORC1) and determine the effect of these polymorphisms on warfarin dose requirements in pediatric patients.