The effect of CYP2C9 and VKORC1 genetic polymorphisms on warfarin dose requirements in a pediatric population

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Taskin B. D., KULA S., ERGÜN M. A., Altun D., Olgunturk R., TUNAOĞLU F. S., ...Daha Fazla

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.16, sa.10, ss.791-796, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 10
  • Basım Tarihi: 2016
  • Doi Numarası: 10.14744/anatoljcardiol.2015.6150
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.791-796
  • Anahtar Kelimeler: CYP2C9, genetic polymorphism, INR, pharmacogenetics, VKORC1, warfarin, PATIENT CHARACTERISTICS, TURKISH POPULATION, IMPACT, FREQUENCY, GENOTYPES, VARIANTS
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: The aim was to investigate the frequency of genetic polymorphisms of cytochrome P4502C9 (CYP2C9) and vitamin K epoxide reductase complex subunit1 (VKORC1) and determine the effect of these polymorphisms on warfarin dose requirements in pediatric patients.