A possible relationship between Toxoplasma gondii and schizophrenia: A seroprevalence study

DOĞRUMAN AL F., ASLAN S., Yalcin S., Kustimur S., Turk S.

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, vol.13, no.1, pp.82-87, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1080/13651500802624738
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.82-87
  • Keywords: Schizophrenia, Toxoplasma gondii, anti-Toxoplasma IgG, anti-Toxoplasma IgM, NECROSIS-FACTOR-ALPHA, ANTIBODIES, INFECTION, INDIVIDUALS, ASSOCIATION, EXPOSURE, AGENTS, CELLS
  • Gazi University Affiliated: Yes


Objective. Schizophrenia is a pervasive neuropsychiatric disease of uncertain etiology. We aimed to investigate a possible association between Toxoplasma gondii infection and schizophrenia in this study. Method. We selected individuals with schizophrenia (n=88) and tested them with commercially available enzyme-linked immunosorbent assay (ELISA) for anti-Toxoplasma IgG and IgM antibodies and compared these seropositivity rate to those of controls without psychiatric disease (n=88). Results. The rate of IgG antibody in the schizophrenia patients (47.7%) was higher than the control groups (20.4%) (P0.001). We did not find any anti-Toxoplasma IgM seropositivity in both schizophrenia patients and control group. In schizophrenic patients with and without anti-Toxoplasma IgG groups statistical analysis did not reveal any correlation between demographic variables and Toxoplasma infection. Conclusion. Our findings supported previous studies indicate that T.gondii may play a role in etiopathogenesis in some cases of schizophrenia.