Matrix metalloproteinase-9 expression correlated with tumor response in patients with locally advanced rectal cancer undergoing preoperative chemoradiotherapy


Unsal D., Uner A., Akyurek N., Erpolat P., Dursun A., Pak Y.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol.67, no.1, pp.196-203, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1016/j.ijrobp.2006.08.010
  • Journal Name: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.196-203
  • Keywords: rectal cancer, radiotherapy, matrix metalloproteinase, gelatinase, preoperative treatment, HUMAN COLORECTAL-CANCER, MATRIX METALLOPROTEINASES, TISSUE INHIBITOR, CHEMORADIATION, CARCINOMA, GELATINASES, REGRESSION, MATRILYSIN, SURVIVAL, THERAPY

Abstract

Purpose: To analyze whether the expression of matrix metalloproteinases (MMPs) and their tissue inhibitors are associated with tumor response to preoperative chemoradiotherapy in rectal cancer patients.