Assessment of anti-inflammatory and free radical scavenger activities of selected Scorzonera species and determination of active components


Bahadir-Acikara O., Küpeli-Akkol E., SÜNTAR İ., Ergene B., Saltan-Çitoğlu G., Çoban T.

International Journal of Pharmacognosy and Phytochemical Research, vol.6, no.3, pp.492-498, 2014 (Scopus) identifier

Abstract

© 2014, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.The aim of the present study is to evaluate anti-inflammatory and antioxidant activities of the S. latifolia, S. mollis ssp. szowitsii, S. suberosa, S. tomentosa and yakı sakızı. Carrageenan, PGE2 and serotonin- induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models were used to evaluate anti-inflammatory activity. Antioxidant capacities were measured using superoxide anion and DPPH radical scavenging methods. Chemical composition of the tested extracts was investigated qualitatively and quantitatively by using RP-HPLC method. S. latifolia, S. mollis ssp. szowitsii, and S. tomentosa exhibited notable inhibition in carrageenan-induced hind paw edema model. S. latifolia and S. tomentosa also showed potent activity against PGE2-induced hind paw edema model as well as in (TPA)-induced mouse ear edema model. All extracts were found to have scavenging activity against DPPH and superoxide anion radicals. Chlorogenic acid was detected as major compounds in yakı sakızı and all the species investigated. Hyperoside was determined as major constituents of aerial part extracts.