Akademik Veri Yönetim Sistemi
GAZI MEDICAL JOURNAL, cilt.35, sa.1, ss.19-23, 2024 (ESCI)
Objective: It is likely that the subgroups of the epidermal growth
factor/platelet-derived growth factor (EGF/PDGF) signaling pathway
play a role in the etiopathogenesis of intrauterine growth restriction
(IUGR). This study was planned to understand the molecular genetic
level of apoptosis in IUGR.
Method: The EGF/PDGF signaling pathway gene profile (40 genes) was
investigated using a real-time reverse transcriptase-polymerase chain
reaction. The gene expressions of the IUGR group were compared
both individually and as a group. Individual gene differences were
also evaluated. The genes related to cell survival and growth, which
include the gene groups of apoptosis, cell cycle, cell differentiation,
cell growth, cell motility, and cell proliferation, were investigated using
microarray technology.
Results: Parity, gestational age at delivery, and APGAR scores at
the first and fifth minutes were not significantly different between
the IUGR and control groups. However, the women in the IUGR
group were younger and slimmer. PRKCA was the only gene with a
significant difference in expression between the IUGR and control
groups. Nevertheless, individual differences were detected in gene
expression associated with cell cycle, differentiation, growth, motility,
proliferation, and apoptosis.
Conclusion: Variations in gene expression during pregnancy cause
changes in placental and fetal development by affecting apoptosis and
cellular events at different levels. The genetic causes of IUGR can be
revealed by investigating these metabolic pathways. This study differs
from previous IUGR studies, which focused on one or a few genes,
because all the gene groups in the EGF/PDGF pathway that may be
associated with IUGR were investigated