Clinical outcome of magnetic activated cell sorting of non-apoptotic spermatozoa before density gradient centrifugation for assisted reproduction

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Dirican E. K., Ozgun O. D., Akarsu S., Akin K. O., Ercan O., Ugurlu M., ...Daha Fazla

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, cilt.25, sa.8, ss.375-381, 2008 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 25 Sayı: 8
• Basım Tarihi: 2008
• Doi Numarası: 10.1007/s10815-008-9250-1
• Dergi Adı: JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.375-381
• Anahtar Kelimeler: Apoptosis, Spermatozoa, Intracytoplasmic sperm injection, Pregnancy rate, PLASMA-MEMBRANE TRANSLOCATION, DNA FRAGMENTATION, HUMAN SPERM, ANNEXIN-V, OXIDATIVE STRESS, EJACULATED SPERM, IN-VITRO, FERTILIZATION, DAMAGE, PHOSPHATIDYLSERINE
• Gazi Üniversitesi Adresli: Hayır

Özet

Purpose Magnetic activated cell sorting (MACS) eliminates apoptotic spermatozoa based on the presence of externalized phosphatidylserine residues. We evaluated the outcome of male fertility treatment when intracytoplasmic sperm injection (ICSI) into human oocytes was performed with non-apoptotic MACS-selected spermatozoa.