An uncommon complementary isochromosome of 46,XY, i(9)(p10),i(9)(q10) in an infertile oligoasthenoteratozoospermic man


Guvendag Guven E. S., Dilbaz S., CEYLANER S., Acar H., Cinar O., Ozdegirmenci O., ...More

Fertility and Sterility, vol.95, no.1, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 95 Issue: 1
  • Publication Date: 2011
  • Doi Number: 10.1016/j.fertnstert.2010.05.028
  • Journal Name: Fertility and Sterility
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Azoospermia, isochromosome, male infertility, nonrobertsonian translocation
  • Gazi University Affiliated: Yes

Abstract

Objective: To report a rare case of male infertility associated with oligoasthenoteratozoospermia and complementary isochromosome 46 XY, i(9)(p10),i(9)(q10). Design: Case report. Setting: Reference hospital. Patient(s): Infertile oligoastenozoospermic man with complementary isochromosome 46,XY, i(9)(p10),i(9)(q10). Intervention(s): Peripheral blood lymphocytes obtained for karyotyping, and florescence in situ hybridization (FISH) analysis for gonadal mosaicism in ejaculated spermatozoa. Main Outcome Measure(s): Physical examination, semen analysis, GBG banding, and FISH procedure. Result(s): The semen analysis revealed oligoasthenoteratozoospermia. The lymphocytic karyotype detected a complementary isochromosome 46,XY, i(9)(p10),i(9)(q10), and the FISH procedure showed abnormal sperm. Conclusion(s): This the first report of oligoasthenoteratozoospermia associated with complementary isochromosome 46,XY, i(9)(p10),i(9)(q10). © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc.