An uncommon complementary isochromosome of 46,XY, i(9)(p10), i(9)(q10) in an infertile oligoasthenoteratozoospermic man

Guvendag Guven E. S., Dilbaz S., CEYLANER S., Acar H., Cinar O., Ozdegirmenci O., ...Daha Fazla

FERTILITY AND STERILITY, sa.1, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.fertnstert.2010.05.028
  • Dergi Adı: FERTILITY AND STERILITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Azoospermia, isochromosome, male infertility, nonrobertsonian translocation
  • Gazi Üniversitesi Adresli: Hayır

Özet

Objective: To report a rare case of male infertility associated with oligoasthenoteratozoospermia and complementary isochromosome 46 XY, i(9)(p10), i(9)(q10). Design: Case report. Setting: Reference hospital. Patient(s): Infertile oligoastenozoospermic man with complementary isochromosome 46, XY, i(9)(p10), i(9)(q10). Intervention(s): Peripheral blood lymphocytes obtained for karyotyping, and florescence in situ hybridization (FISH) analysis for gonadal mosaicism in ejaculated spermatozoa. Main Outcome Measure(s): Physical examination, semen analysis, GBG banding, and FISH procedure. Result(s): The semen analysis revealed oligoasthenoteratozoospermia. The lymphocytic karyotype detected a complementary isochromosome 46, XY, i(9)(p10), i(9)(q10), and the FISH procedure showed abnormal sperm. Conclusion(s): This the first report of oligoasthenoteratozoospermia associated with complementary isochromosome 46, XY, i(9)(p10), i(9)(q10). (Fertil Steril (R) 2011;95:290.e5-e8. (C) 2011 by American Society for Reproductive Medicine.)