An uncommon complementary isochromosome of 46,XY, i(9)(p10), i(9)(q10) in an infertile oligoasthenoteratozoospermic man
FERTILITY AND STERILITY, sa.1, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Editöre Mektup
- Basım Tarihi: 2011
- Doi Numarası: 10.1016/j.fertnstert.2010.05.028
- Dergi Adı: FERTILITY AND STERILITY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Azoospermia, isochromosome, male infertility, nonrobertsonian translocation
- Gazi Üniversitesi Adresli: Hayır
Özet
Objective: To report a rare case of male infertility associated with oligoasthenoteratozoospermia and complementary isochromosome 46 XY, i(9)(p10), i(9)(q10). Design: Case report. Setting: Reference hospital. Patient(s): Infertile oligoastenozoospermic man with complementary isochromosome 46, XY, i(9)(p10), i(9)(q10). Intervention(s): Peripheral blood lymphocytes obtained for karyotyping, and florescence in situ hybridization (FISH) analysis for gonadal mosaicism in ejaculated spermatozoa. Main Outcome Measure(s): Physical examination, semen analysis, GBG banding, and FISH procedure. Result(s): The semen analysis revealed oligoasthenoteratozoospermia. The lymphocytic karyotype detected a complementary isochromosome 46, XY, i(9)(p10), i(9)(q10), and the FISH procedure showed abnormal sperm. Conclusion(s): This the first report of oligoasthenoteratozoospermia associated with complementary isochromosome 46, XY, i(9)(p10), i(9)(q10). (Fertil Steril (R) 2011;95:290.e5-e8. (C) 2011 by American Society for Reproductive Medicine.)