Akademik Veri Yönetim Sistemi
JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 2025 (ESCI)
Purpose This study aimed to compare the bone regenerative effects of different doses of strontium ranelate (SR) with those of BMP-2, by applying collagen sponges (CS) absorbed with two concentrations of SR and BMP-2 to a rat calvarial defect model and evaluating the outcomes through histological and immunohistochemical analyses. Material and Methods Critical-sized calvarial defects created on 34 male Long Evans rats. The defects were left empty or filled with only CS, CS absorbed with 0.25 mM SR (CS + 0.25 SR), CS absorbed with 0.5 mM SR (CS + 0.5 SR), and CS absorbed with 0.1 mg/ml rHBMP-2 (CS + BMP-2). Samples taken at the end of 8 weeks post-operation were examined histologically and immunohistochemically. Results There was no significant difference in the percentage of new bone formation (NBF) between the CS and SR groups, while the BMP-2 group showed a higher NBF level than the CS. There was no significant difference in the percentage of NBF between the 0.25 SR group and the BMP-2 group (p < 0.001). In osteocalcin analysis, the BMP-2 group exhibited a higher immune positive compared to the other groups. Conclusion 0.25 mM SR showed comparable osteogenic potential to BMP-2, while the higher 0.5 mM SR dose was ineffective, possibly due to carrier limitations or dose-related suppression of bone formation.