SISTER-CHROMATID EXCHANGES IN EPILEPTIC PATIENTS ON ANTICONVULSANT THERAPY


SARDAS S., ADA M., KARAKAYA A., AYDIN N.

MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS, vol.313, no.1, pp.21-24, 1994 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 313 Issue: 1
  • Publication Date: 1994
  • Doi Number: 10.1016/0165-1161(94)90029-9
  • Title of Journal : MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS
  • Page Numbers: pp.21-24

Abstract

Sister-chromatid exchanges (SCE) have been studied to analyze genotoxic effects in epileptic patients on anticonvulsant therapy. All patients had an increased frequency of SCE per metaphase (p < 0.001) compared to controls, indicating a genotoxic effect of anticonvulsant drugs.