Akademik Veri Yönetim Sistemi
6th International Congress on Innovative Scientific Approaches, Türkiye, 19 - 20 Aralık 2021, ss.461
In recent years, the number of scientific
studies, which is accelerated with the developing technology, especially in the
fields of biology, chemistry, and pharmacy has increased considerably. The
current trend in drug release is developing rapidly and the controlled release
systems approach, which releases the drug at a pre-planned speed and time, stands
out. Controlled drug release system is a very important technique that reduces the
fluctuations in drug concentration in blood, preserves the bioactivity of the
drug and increases its effectiveness, and reduces drug resistance and side
effects. As a non-steroidal, anti-inflammatory, antipyretic, and potent
analgesic, Naproxen, has a variety of gastrointestinal side effects, including
peptic ulcer and gastritis, in oral administration. In the first step of our
current study, it has been aimed to reduce the possible side effects of
naproxen by creating controlled release from microparticular systems. For this purpose, encapsulation of naproxen with
different ratios of biocompatible and natural polymers (2% w/v) sodium alginate
and (3% w/v) pectin was carried out by emulsion technique. In the second step
of our study, the formed microspheres were embedded in gelatin films which were
added propolis, anti-bacterial, anti-fungal, anti-viral, antioxidant, local
anesthetic, and anti-inflammatory. The release studies from the formed
microsphere embedded films and the water holding capacity of the films and
microspheres were investigated. The antioxidant activities of the films were
evaluated by their capacity to scavenge the 2,2-diphenyl-1-picrylhydrazil
(DPPH) radical. Characterization studies were performed by scanning electron
microscopy (SEM), Fouirer transform ınfrared spectrophotometer (FTIR) and differential
scanning calorimetry (DSC) analyzes. With the films obtained in this study, it
was aimed to create an innovative transdermal controlled drug release system
that shows topical performance on the skin and improves therapeutic properties
by prolonging drug release.