Bovine papillomavirus type 2 infects the urinary bladder of water buffalo (Bubalus bubalis) and plays a crucial role in bubaline urothelial carcinogenesis


Roperto S., Russo V., Ozku A., SEPİCİ DİNÇEL A. , Maiolino P., Borzacchiello G., ...Daha Fazla

JOURNAL OF GENERAL VIROLOGY, cilt.94, ss.403-408, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 94
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1099/vir.0.047662-0
  • Dergi Adı: JOURNAL OF GENERAL VIROLOGY
  • Sayfa Sayıları: ss.403-408

Özet

Bovine papillomavirus type 2 (BPV-2) has been shown to infect and play a role in urinary bladder carcinogenesis of buffaloes grazed on pastures with ferns from the Marmara and Black Sea Regions of Turkey. BPV-2 DNA has been found in both neoplastic and non-neoplastic lesions of the urinary bladder. Furthermore, this virus may be a normal inhabitant of the urinary bladder since BPV-2 DNA has also been detected in clinically normal buffaloes. The viral activation by fern immunosuppressant or carcinogen may trigger the urothelial cell transformation. The E5 oncoprotein was solely detected in urothelial tumours and appeared to be co-localized with the overexpressed and phosphorylated platelet derived growth factor (PDGF) beta receptor in a double-colour immunofluorescence assay. Our results indicate that the E5-PDGF beta receptor interaction also occurs in spontaneous tumours of the bubaline urinary bladder, revealing an additional role of BPV-2 in bladder carcinogenesis of buffaloes.