The efficacy and toxicity of irinotecan with leucovorin and bolus and continuous infusional 5-fluorouracil (FOLFIRI) as salvage therapy for patients with advanced gastric cancer previously treated with platinum and taxane-based chemotherapy regimens

Kaya A. O., Coskun U., Gumus M., Dane F., ÖZKAN M., Isikdogan A., ...Daha Fazla

JOURNAL OF CHEMOTHERAPY, cilt.24, sa.4, ss.217-220, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1179/1973947812y.0000000020
  • Dergi Adı: JOURNAL OF CHEMOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.217-220
  • Anahtar Kelimeler: Advanced gastric cancer, Salvage therapy, FOLFIRI regimen, HIGH-DOSE LEUCOVORIN, PHASE-III TRIAL, 1ST-LINE THERAPY, SUPPORTIVE CARE, PLUS CISPLATIN, FLUOROURACIL, FLUOROPYRIMIDINE, COMBINATION, ESOPHAGEAL, CARCINOMA
  • Gazi Üniversitesi Adresli: Evet

Özet

There is no established standard salvage chemotherapy in the second-line setting for patients with advanced gastric cancer (AGC) pre-treated with platinum and taxane-based chemotherapy. Our study aims to evaluate the safety and efficacy of FOLFIRI regimen (irinotecan with leucovorin and bolus and continuous infusion with 5-fluorouracil) as a salvage chemotherapy regimen in patients with AGC. Medical records of 97 patients with AGC who received second-line FOLFIRI regimen between March 2006 and February 2011 were examined. Complete and partial responses were observed in 3 (3.1%) and 23 (23.7%) patients, respectively. The median time to progression (TTP) was 3.5 months (95% CI: 2.4-4.6) and the median overall survival (OS) was 10.5 months (95% CI: 8.8-12.2). The most common observed grade 3/4 toxicities were neutropenia (23.7%), diarrhea (6.2%), and stomatitis (5.2%). FOLFIRI regimen is safe and effective in the second-line treatment of AGC patients pre-treated with cisplatin and taxanes.