Overexpression of the local bone marrow renin-angiotensin system in acute myeloid leukemia


BEYAZIT Y., Aksu S., Haznedaroglu I. C. , KEKİLLİ M., Misirlioglu M., Tuncer S., ...More

JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION, vol.99, no.1, pp.57-63, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 99 Issue: 1
  • Publication Date: 2007
  • Journal Name: JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.57-63
  • Keywords: renin-angiotensin system, myeloid leukemia, angiotensin-converting enzyme, reverse transcription-polymerase chain reaction, I-CONVERTING-ENZYME, HEMATOPOIETIC STEM, TETRAPEPTIDE ACSDKP, PROGENITOR CELLS, PROLIFERATION, HYPOTHESIS, EXPRESSION, VIVO, ACE, IRRADIATION
  • Gazi University Affiliated: No

Abstract

Objectives: Local bone marrow renin-angiotensin system (RAS) is an autocrine-paracrine system affecting hematopoiesis. Angiotensin II stimulates the proliferation of bone marrow and umbilical cord blood hematopoietic progenitors. Angiotensin converting enzyme (ACE) hyperfunction may lead to the acceleration of negative hematopoietic regulator peptide, AcSDKP, metabolism, which in turn lowers its level in the bone marrow microenvironment, finally removing the antiproliferative effect of AcSDKP on the hematopoietic cells and blasts. The aim of this study is therefore to search those major RAS components simultaneously in the leukemic blast cells taken from the bone marrow of patients with acute myeloid leukemia (AML).