The effect of levosimendan on lung damage after myocardial ischemia reperfusion in rats in which experimental diabetes was induced


ALKAN M., ÇELİK A., Bilge M., KİRAZ H. A. , KİP G., ÖZER A., ...More

JOURNAL OF SURGICAL RESEARCH, vol.193, no.2, pp.920-925, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 193 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jss.2014.08.038
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.920-925
  • Keywords: Diabetes mellitus, Levosimendan, Ischemia-reperfusion, Distant organ damage, Rat, Antioxidant system, LIPID-PEROXIDATION, INJURY, ISCHEMIA/REPERFUSION, MICROCIRCULATION, ILOPROST
  • Gazi University Affiliated: Yes

Abstract

Background: It is known that diabetic complications and lipid peroxidation are closely associated. During ischemia and reperfusion (IR), injury may occur in distant organs, as well as in tissues next to the region exposed to the ischemia, and the lungs can be one of the most affected of these organs. Therefore, this study investigated the effects of levosimendan on lung tissue and the oxidant-antioxidant system in diabetic rats.