2-Sulfanylidene-2,3-dihydropyridopyrimidin-4(1H)-one Derivatives: Synthesis, Reactions and Biological Activities 2-Sülfaniliden-2,3-dihidropiridopirimidin-4(1H)-on Türevleri: Sentezi, Reaksiyonları ve Biyolojik Aktiviteleri

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GÜNEŞ F., KUYRUKÇU ÖZTÜRK Ö., DÜNDAR Y.

Fabad Journal of Pharmaceutical Sciences, cilt.51, sa.2, ss.1059-1086, 2026 (Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 2
  • Basım Tarihi: 2026
  • Doi Numarası: 10.55262/fabadeczacilik.1889330
  • Dergi Adı: Fabad Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus, EMBASE, Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
  • Sayfa Sayıları: ss.1059-1086
  • Anahtar Kelimeler: 2-sulfanylidene-2,3-dihydropyridopyrimidin-4(1H)-one, Pyrido[2,3-d]pyrimidine, pyrido[3,2-d]pyrimidine, pyrido[3,4-d]pyrimidine, pyrido[4,3-d]pyrimidine
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Gazi Üniversitesi Adresli: Evet

Özet

This review presents a comprehensive examination of the synthesis, structural modifications, and biological activities of the 2-sulfanylidene-2,3-dihydropyridopyrimidin-4(1H)-one ring systems. The study is organized into four main sections covering compounds possessing the core structures of pyrido[2,3-d]-, pyrido[3,4-d]-, pyrido[4,3-d]-, and pyrido[3,2-d]pyrimidines. Common synthetic strategies frequently used in the synthesis of these fused rings, such as reactions of aminopyridinecarboxylic acid derivatives with thiourea, ammonium thiocyanate, or isothiocyanates, are summarized, with a particular focus on structural modifications performed at the 2- and 3-positions of the rings. In the case of pyrido[2,3-d]pyrimidine derivatives, the reactions of the widely reported 6-amino-2-sulfanylpyrimidin-4(3H)-one compound with β-dicarbonyl compounds or α,β-unsaturated carbonyl derivatives are comprehensively discussed. In addition, the pharmacological effects of the 2-sulfanylidene-2,3-dihydropyridopyrimidin-4(1H)-one ring system, particularly its anticancer activities, are highlighted, underscoring the importance of this scaffold in medicinal chemistry.