In vivo gastroprotective effects of five Turkish folk remedies against ethanol-induced lesions

Gurbuz İ., Ustun O., Yesilada E., Sezik E., Akyurek N.

JOURNAL OF ETHNOPHARMACOLOGY, vol.83, no.3, pp.241-244, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 83 Issue: 3
  • Publication Date: 2002
  • Doi Number: 10.1016/s0378-8741(02)00248-9
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.241-244
  • Keywords: anti-ulcerogenic activity, Asphodelus aestivus, Cichorium intybus, cytoprotective effect, Equisetum palustre, ethanol-induced gastric ulcer, histopathology, Laurus nobilis, Viscum album ssp album
  • Gazi University Affiliated: Yes


Through evaluation of the data accumulated in Data Bank of Turkish Folk Remedies (TUHIB), five plant remedies, which are used to treat stomach ache were selected to test for their anti-ulcerogenic potency. In order to confirm the claimed activities, either decoction or methanol extracts were prepared from the roots of Asphodelus aestivus and Cichorium intybus, herbs of Equisetum palustre and Viscum album ssp. album and fruits of Laurus nobilis, according to their folkloric application way and tested for their effects on ethanol-induced gastric ulcer model in rats. Pharmacological experiments clearly demonstrated that the relevant extracts of all the plants given orally showed significant stomach protection against this model of ulcerogenesis. Results were further evaluated by using histopathological techniques. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.