Protective role of sodium selenite and vitamin E against rat erythrocytes induced by mercury chloride


KALENDER S., APAYDIN F. G., UZUNHİSARCIKLI M., ASLANTÜRK A.

GAZI UNIVERSITY JOURNAL OF SCIENCE, vol.27, no.4, pp.1123-1129, 2014 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 4
  • Publication Date: 2014
  • Journal Name: GAZI UNIVERSITY JOURNAL OF SCIENCE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.1123-1129
  • Keywords: Mercury chloride, Sodium selenite, Vitamin E, Erythrocytes, Oxidative stress, INDUCED OXIDATIVE STRESS, DAMAGE, LIVER, ASSAY, ZINC
  • Gazi University Affiliated: Yes

Abstract

The aim of this study was to investigate the effect of subacute mercury chloride exposure on lipid peroxidation and activities of antioxidant enzymes and the possible protective effect of sodium selenite and/or vitamin E. For this purpose, male Wistar rats were divided into eight groups. It was shown that exposure to mercury chloride caused a significant increase in MDA, while significant decrease in SOD, CAT, GPx, GST activities in erythrocytes. Sodium selenite and vitamin E administration had a beneficial effect on the mercury chloride induced oxidative stress. Our results implicate mercury chloride-induced oxidative stress in erythrocytes protected by sodium selenite and vitamin E.