Unusual presentation of familial Mediterranean fever with co-existing polyarteritis nodosa and acute post-streptococcal glomerulonephritis


Ozdemir Atikel Y., DERİNKUYU B. E. , BAKKALOĞLU EZGÜ S. A.

CLINICAL CASE REPORTS, vol.10, no.7, 2022 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 7
  • Publication Date: 2022
  • Doi Number: 10.1002/ccr3.6022
  • Journal Name: CLINICAL CASE REPORTS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, Directory of Open Access Journals
  • Keywords: case report, familial Mediterranean fever, polyarteritis nodosa, post-streptococcal acute glomerulonephritis, VASCULITIS
  • Gazi University Affiliated: Yes

Abstract

Acute post-streptococcal glomerulonephritis (APSGN) and polyarteritis nodosa (PAN) may occur simultaneously after streptococcal infection in a child who is previously healthy but carries a Mediterranean fever (MEFV) mutation. The homozygous M694V mutation in the MEFV gene may cause an augmented response to the streptococcal infection that plays a role in the development of both clinical manifestations.