Unusual presentation of familial Mediterranean fever with co-existing polyarteritis nodosa and acute post-streptococcal glomerulonephritis

Ozdemir Atikel Y., DERİNKUYU B. E., BAKKALOĞLU EZGÜ S. A.

CLINICAL CASE REPORTS, cilt.10, sa.7, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 7
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/ccr3.6022
  • Dergi Adı: CLINICAL CASE REPORTS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, Directory of Open Access Journals
  • Anahtar Kelimeler: case report, familial Mediterranean fever, polyarteritis nodosa, post-streptococcal acute glomerulonephritis, VASCULITIS
  • Gazi Üniversitesi Adresli: Evet

Özet

Acute post-streptococcal glomerulonephritis (APSGN) and polyarteritis nodosa (PAN) may occur simultaneously after streptococcal infection in a child who is previously healthy but carries a Mediterranean fever (MEFV) mutation. The homozygous M694V mutation in the MEFV gene may cause an augmented response to the streptococcal infection that plays a role in the development of both clinical manifestations.