Synthesis and antinociceptive activity of some 3-substituted benzothiazolone derivatives

Cakir B., Ulucay A., DOĞRUER D. S. , Isimer A., Sahin M.

FARMACO, vol.54, pp.846-851, 1999 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54
  • Publication Date: 1999
  • Doi Number: 10.1016/s0014-827x(99)00111-1
  • Journal Name: FARMACO
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.846-851


Thirteen 3-substituted benzothiazolone derivatives have been synthesized. Their chemical structures have been elucidated by IR and NMR spectral data and by elemental analyses. Among these compounds, 1-{3-[2(3H)-benzothiazolon-3-yl]propanoyl}morpholine (5b); 1-{3-[2(3H)-benzothiazolon-3-yl]propanoyl}-4-benzylpiperidine (5c); 1-{3-[2(3H)-benzothiazolon-3-yl]propanoyl}-4-phenylpiperazine (5d); 3-[3-(4-benzylpiperidine-1-yl)propyl]-2(3H)-benzothiazolone (Sk); 3-[3-(4-benzylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5I); 3-[3-(4-phenylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5m) have been found to be significantly more active than the others. (C) 1999 Elsevier Science S.A. All rights reserved.