E-cadherin gene 3 '-UTR C/T polymorphism in Turkish patients with nephrolithiasis


Yilmaz A., Menevse S., ONARAN M. , ŞEN İ. , ERGÜN M. A. , Camtosun A., ...Daha Fazla

MOLECULAR BIOLOGY REPORTS, cilt.38, sa.8, ss.4931-4934, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Konu: 8
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1007/s11033-010-0635-8
  • Dergi Adı: MOLECULAR BIOLOGY REPORTS
  • Sayfa Sayıları: ss.4931-4934

Özet

Nephrolithiasis is a complex disease and many gene polymorphisms have been associated with stone formation. In this study we aimed to investigate another possible relationship between E-cadherin gene (CHD1) 3'-UTR C/T polymorphism and calcium oxalate nephrolithiasis in the Turkish population. Study population was composed of 143 patients with nephrolithiasis and 158 control subjects. CHD1 3'-UTR C/T polymorphism was analysed using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) technique. Genotype distribution of the investigated polymorphism was not deviated from Hardy-Weinberg equilibrium (HWE) in patients and control subjects (P > 0.05). C allele frequency was 85.7 and 85.1% in patients and controls, respectively (P = 0.836). Genotype distributions of the CHD1 3'-UTR C/T polymorphism among patients were also not significantly different from those among control subjects (P = 0.636). Our results showed that there is no association between the CHD1 gene 3'-UTR C/T polymorphism and nephrolithiasis in our population.