Miller-Fisher syndrome associated with chronic lymphocytic leukemia

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Aki Z., Aksoy O., Sucak G., Kuruoglu R., Yagci M.

NEUROLOGY INDIA, vol.56, no.2, pp.198-200, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 2
  • Publication Date: 2008
  • Doi Number: 10.4103/0028-3886.42003
  • Journal Name: NEUROLOGY INDIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.198-200
  • Keywords: chronic lymphocytic leukemia, Miller-Fisher syndrome, plasmapheresis, POLYNEUROPATHY
  • Gazi University Affiliated: Yes

Abstract

Chronic lymphocytic leukemia (CLL) is a frequent hematological malignancy, with meningeal or peripheral nerve infiltrations being the most commonly encountered neurological complications. In this report, we describe a CLL patient with Miller-Fisher syndrome (MFS) who responded to immune modulation with plasmapheresis. A 47-year-old man diagnosed as B-cell CLL admitted with neutropenic fever. He complained of diplopia and numbness of both arms. Neurological examination revealed a bilateral external ophthalmoplegia, dysphagia, dysarthria, mild shoulder girdle muscle weakness and gait ataxia, accompanied by absent tendon reflexes. Nerve conduction studies were indicative of a predominantly axonal sensori-motor peripheral neuropathy. This association of CLL with MFS had not been previously reported in the literature.