Miller-Fisher syndrome associated with chronic lymphocytic leukemia.


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Aki Z., Aksoy O., Sucak G., Kuruoglu R. , Yagci M.

Neurology India, cilt.56, ss.198-200, 2008 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 56 Konu: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.4103/0028-3886.42003
  • Dergi Adı: Neurology India
  • Sayfa Sayıları: ss.198-200

Özet

Chronic lymphocytic leukemia (CLL) is a frequent hematological malignancy, with meningeal or peripheral nerve infiltrations being the most commonly encountered neurological complications. In this report, we describe a CLL patient with Miller-Fisher syndrome (MFS) who responded to immune modulation with plasmapheresis. A 47-year-old man diagnosed as B-cell CLL admitted with neutropenic fever. He complained of diplopia and numbness of both arms. Neurological examination revealed a bilateral external ophthalmoplegia, dysphagia, dysarthria, mild shoulder girdle muscle weakness and gait ataxia, accompanied by absent tendon reflexes. Nerve conduction studies were indicative of a predominantly axonal sensori-motor peripheral neuropathy. This association of CLL with MFS had not been previously reported in the literature.