Neurological soft signs in schizophrenia and obsessive compulsive disorder spectrum

Tumkaya S., KARADAĞ R. F. , Oguzhanoglu N. K.

EUROPEAN PSYCHIATRY, cilt.27, sa.3, ss.192-199, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Konu: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.eurpsy.2010.03.005
  • Sayfa Sayıları: ss.192-199


Obsessive compulsive symptoms are more frequent in patients with schizophrenia compared to normal population. Patients with obsessive compulsive disorder may also exhibit psychosis-like symptoms. Based on these findings, it has been suggested that there is a spectrum of disorders between OCD and schizophrenia. We compared two OCD groups (with good and poor insight) and two schizophrenia groups (with and without OCD) in this recommended spectrum especially in terms of neurological soft signs (NSSs) associated with sensory integration. The schizophrenia with OCD (schizo-obsessive) group exhibited worse performance than the schizophrenia group (p = 0.002) in only graphesthesia tasks. Moreover, schizo-obsessive patients exhibited worse performance compared to OCD patients in terms of graphesthesia (p = 0.001) and audiovisual integration (p = 0.001). Interestingly, OCD patients with poor insight tended to exhibit graphesthesia deficit in a similar manner to schizo-obsessive patients rather than OCD patients. According to our results, graphesthesia disorder is strongly associated both with OCD and schizophrenia. This suggests that neurodeveloprnental disorders that lead to graphesthesia disorder overlap in comorbid OCD and schizophrenia patients. (C) 2010 Elsevier Masson SAS. All rights reserved.