Intracranial hypotension is a clinical syndrome of decrease in volume or pressure of cerebrospinal fluid (CSF), presenting with orthostatic headache. It is diagnosed by typical clinical presentation and documentation of decrease in CSF pressure, along with the radiological findings. The first treatment option is conservative; bed rest, fluid replacement, caffeine, theophylline, abdominal bandage. If pain persists, epidural blood patch is considered the gold standard treatment. In this article patients resistant to medical treatment were treated with epidural blood patch for different etiologies; also diagnosis, radiological features and treatment approaches were discussed.