Association between the 196G > A (VAL66 MET) and -1360C > T (C-270T) polymorphisms of the brain-derived neurotrophic factor gene and bipolar disorder


Demiryurek S., Savas H. A. , Igci M., Herken H., Gorucu S., Kara A. F. , ...More

NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH, vol.13, no.3, pp.125-130, 2006 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 2006
  • Journal Name: NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.125-130
  • Gazi University Affiliated: No

Abstract

Backgrounds: Bipolar disorder is a severe psychiatric disease, characterized by recurrent manic and depressive episodes, and is believed to have a strong genetic component. Several data suggest that the brain-derived neurotrophic factor (BDNF) gene is a potential candidate gene for this affective disease. The aim of this study was to test a possible association between the BDNF gene polymorphisms and bipolar disorder in a Turkish population.