Association between the 196G > A (VAL66 MET) and -1360C > T (C-270T) polymorphisms of the brain-derived neurotrophic factor gene and bipolar disorder

Demiryurek, Seniz; Savas, Haluk; Igci, Mehri; Herken, Hasan; Gorucu, Senay; Kara, Ali; Selek, Salih; Oguzkan, Sibel; Bulbul, Feridun; Arslan, Ahmet; Demiryurek, Abdullah

Association between the 196G > A (VAL66 MET) and -1360C > T (C-270T) polymorphisms of the brain-derived neurotrophic factor gene and bipolar disorder

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Demiryurek S., Savas H. A., Igci M., Herken H., Gorucu S., Kara A. F., ...More

NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH, vol.13, no.3, pp.125-130, 2006 (SCI-Expanded)

Publication Type: Article / Article
Volume: 13 Issue: 3
Publication Date: 2006
Journal Name: NEUROLOGY PSYCHIATRY AND BRAIN RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.125-130
Gazi University Affiliated: No

Abstract

Backgrounds: Bipolar disorder is a severe psychiatric disease, characterized by recurrent manic and depressive episodes, and is believed to have a strong genetic component. Several data suggest that the brain-derived neurotrophic factor (BDNF) gene is a potential candidate gene for this affective disease. The aim of this study was to test a possible association between the BDNF gene polymorphisms and bipolar disorder in a Turkish population.