Vertical transmission of SARS CoV-2: a systematic review

Deniz M., TEZER H.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.35, no.14, pp.2655-2662, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 35 Issue: 14
  • Publication Date: 2022
  • Doi Number: 10.1080/14767058.2020.1793322
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.2655-2662
  • Keywords: Vertical transmission, COVID-19, neonatal, SARS CoV-2, pregnancy, SYNDROME CORONAVIRUS 2, CLINICAL ANALYSIS, COVID-19, SARS-COV-2, MOTHERS, PREGNANCY, RNA
  • Gazi University Affiliated: Yes


Objective The aim of this study is to review the current evidence on the vertical transmission of SARS CoV-2. Methods Combination of the following keywords; COVID-19, SARS CoV-2, placenta, vertical transmission, intrauterine infection, breast milk were searched in databases. Results In the 50 studies included, 17 newborns testing positive for SARS CoV-2 by RT-PCR were reported. In three neonates, SARS-CoV-2 IgG and IgM levels were elevated. Eight placental tissues testing positive for the virus were reported. Three positive RT-PCR results of test of breast milk have been reported recently. One amniotic fluid testing positive was reported. Conclusion Possible vertical transmission of SARS CoV-2 has been observed in some studies currently. More RT-PCR tests on amniotic fluid, placenta, breast milk and cord blood are required.