The contribution of vitamin C to healing of experimental fractures

Yimaz C., Erdemli E., Selek H., Kinik H., ARIKAN Ş. M., Erdemli B.

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY, vol.121, no.7, pp.426-428, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121 Issue: 7
  • Publication Date: 2001
  • Doi Number: 10.1007/s004020100272
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.426-428
  • Keywords: vitamin C, fracture healing, rat
  • Gazi University Affiliated: No


The benefits of various minerals and vitamins on fracture healing have been demonstrated in animal models. Vitamin C is an essential substance in fracture healing but has not been studied previously on an experimental basis. Sixteen rats were grouped randomly into control and vitamin C-supplemented groups. The right tibias of all rats were fractured by digital manipulation. One group received single high dose of vitamin C intramuscularly. On the 5th, 10th, 15th, and 20th days, two rats from each group were killed and the tibias examined under light microscopy. It was seen that the vitamin C-supplemented group went through the stages of fracture healing faster compared with the control group.