Neuroprotective Effects of Quetiapine on Neuronal Apoptosis Following Experimental Transient Focal Cerebral Ischemia in Rats

Yilmaz M. B., Tonge M., Emmez H., Kaymaz F., Kaymaz M.

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, cilt.54, sa.1, ss.1-7, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3340/jkns.2013.54.1.1
  • Dergi Adı: JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-7
  • Anahtar Kelimeler: Quetiapine, Neuronal apoptosis, Neuroprotective, Transient focal cerebral ischemia, SPINAL-CORD-INJURY, ATYPICAL ANTIPSYCHOTIC-DRUGS, PLACEBO-CONTROLLED TRIAL, PROTECT PC12 CELLS, ARTERY OCCLUSION, BRAIN ISCHEMIA, DOUBLE-BLIND, CDP-CHOLINE, HYDROXYL RADICALS, MILD HYPOTHERMIA
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective : This study was undertaken in the belief that the atypical antipsychotic drug quetiapine could prevent apoptosis in the penumbra region following ischemia, taking into account findings that show 5-hydroxytryptamine-2 receptor blockers can prevent apoptosis.