Evaluation of malignant and benign lung lesions with Tc-99(m)-tetrofosmin

Atasever T., Gokcora N., Vural G., Cetin N., Ozturk C., Unlu M.

NUCLEAR MEDICINE COMMUNICATIONS, cilt.17, sa.7, ss.577-582, 1996 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Konu: 7
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1097/00006231-199607000-00007
  • Sayfa Sayıları: ss.577-582


Tc-99(m)-tetrofosmin planar imaging was performed in 30 patients with malignant and benign lung lesions. There were 21 cases of primary lung cancer (10 squamous cell, 5 small cell, 4 adenocarcinoma and 2 large cell) and 9 benign lung lesions (4 pneumonia, 3 tuberculosis, 1 infected bronchiectasis and 1 bronchiolitis obliterans). Anterior and posterior planar thorax images were obtained 30 min after the intravenous injection of 740 MBq (20 mCi) of Tc-99(m)-tetrofosmin. Visual and quantitative evaluations were performed. For the quantitative evaluation, regions of interest were drawn over the lesioned area (L) and over the contralateral non-lesioned area (N). Of 21 malignant primary lesions; 19 (90%) showed Tc-99(m)-tetrofosmin accumulation. Four (44%) of the nine benign lung lesions (3 cases of pneumonia and the one case of active tuberculosis) showed uptake. The mean L/N ratios for the malignant and benign lesions were 1.63 +/- 0.29 and 1.64 +/- 0.19, respectively. There were no significant differences (P > 0.05) in the L/N ratios of the malignant and benign lesions or the various histological types of cancer. In conclusion, Tc-99(m)-tetrofosmin was highly sensitive (90%) in detecting malignant lung lesions, but it had poor specificity (55%).