Interaction of lidocaine with reactive oxygen and nitrogen species

Günaydın D. B., Demiryurek A.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, vol.18, pp.816-822, 2001 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18
  • Publication Date: 2001
  • Doi Number: 10.1046/j.1365-2346.2001.00931.x
  • Journal Name: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.816-822
  • Keywords: anaesthetics, local, lidocaine, blood cells, leukocytes, free radicals, luminescence, chemiluminescence, SUPEROXIDE ANION PRODUCTION, HUMAN POLYMORPHONUCLEAR LEUKOCYTES, LOCAL-ANESTHETICS, CHEMI-LUMINESCENCE, HUMAN NEUTROPHILS, LYSOSOMAL-ENZYME, NITRIC-OXIDE, CHEMILUMINESCENCE, PEROXYNITRITE, INHIBITION
  • Gazi University Affiliated: Yes

Abstract

Background and objective To investigate the ability of lidocaine to inhibit reactive oxygen and/or nitrogen species generation by either human leukocytes or cell-free systems via luminol- and lucigenin-enhanced chemiluminescence.