An investigation of the interfacial interaction between poly(acrylic acid) and glycoprotein

Degim Z., Kellaway I.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol.175, no.1, pp.9-16, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 175 Issue: 1
  • Publication Date: 1998
  • Doi Number: 10.1016/s0378-5173(98)00215-4
  • Journal Name: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.9-16
  • Keywords: mucoadhesion, microsphere, swelling poly(acrylic acid), glycoprotein, ATR-FTIR spectroscopy, POLYMER
  • Gazi University Affiliated: No

Abstract

The swelling behaviour of poly(acrylic acid) microspheres, produced from poly(acrylic acid) crosslinked with maltose, was investigated as a function of time by using a laser diffraction spectrometer. Swelling was also studied in various pH glycoprotein solutions. Microscopy revealed cofirmatory evidence of interfacial film formation when microsphere hydration occurred in a pH 5 glycoprotein solution. ATR-FTIR spectroscopy was used to determine the diffusion coefficient of water through the interfacial film existing at the poly(acrylic acid) glycoprotein solution interface. Both processes exhibited a pH dependency with rates decreasing in the sequence pH 7 > 6 > 5 = 4. (C) 1998 Elsevier Science B.V. All rights reserved.