An investigation of the interfacial interaction between poly(acrylic acid) and glycoprotein


Degim Z., Kellaway I.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.175, sa.1, ss.9-16, 1998 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 175 Konu: 1
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1016/s0378-5173(98)00215-4
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Sayfa Sayıları: ss.9-16

Özet

The swelling behaviour of poly(acrylic acid) microspheres, produced from poly(acrylic acid) crosslinked with maltose, was investigated as a function of time by using a laser diffraction spectrometer. Swelling was also studied in various pH glycoprotein solutions. Microscopy revealed cofirmatory evidence of interfacial film formation when microsphere hydration occurred in a pH 5 glycoprotein solution. ATR-FTIR spectroscopy was used to determine the diffusion coefficient of water through the interfacial film existing at the poly(acrylic acid) glycoprotein solution interface. Both processes exhibited a pH dependency with rates decreasing in the sequence pH 7 > 6 > 5 = 4. (C) 1998 Elsevier Science B.V. All rights reserved.