Mitomycin C decreases the rate of stricture formation in caustic esophageal burns in rats

TÜRKYILMAZ Z., SÖNMEZ K., KARABULUT R., Guelbahar Ö., POYRAZ A., Sancak B., ...More

SURGERY, vol.145, no.2, pp.219-225, 2009 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 145 Issue: 2
  • Publication Date: 2009
  • Doi Number: 10.1016/j.surg.2008.10.007
  • Journal Name: SURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.219-225


Background. Although the incidence of caustic ingestion is declining, the management of caustic esophageal strictures remains a challenge. Although many agents have been tried experimentally to treat strictures, few have gained clinical application. The aim of this study was to investigate the influence of mitomycin C (MMC), which inhibits fibroblastic proliferation in treating delayed caustic esophageal strictures.