3-(4-Aminobutyn-1-y1)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors


DOĞRUER D. S. , Lee M., Dukat M., Damaj I., Martin B., Glennon R.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.14, no.2, pp.523-526, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1016/j.bmcl.2003.10.033
  • Title of Journal : BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
  • Page Numbers: pp.523-526

Abstract

The binding of a series pyridylbutynylamines 6 was examined at alpha4beta2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models. (C) 2003 Elsevier Ltd. All rights reserved.