3-(4-Aminobutyn-1-y1)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors

DOĞRUER, DENİZ; Lee, M; Dukat, M; Damaj, I; Martin, BR; Glennon, RA

doi:10.1016/j.bmcl.2003.10.033

3-(4-Aminobutyn-1-y1)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors

Atıf İçin Kopyala

DOĞRUER D. S., Lee M., Dukat M., Damaj I., Martin B., Glennon R.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.14, sa.2, ss.523-526, 2004 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 14 Sayı: 2
Basım Tarihi: 2004
Doi Numarası: 10.1016/j.bmcl.2003.10.033
Dergi Adı: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.523-526
Gazi Üniversitesi Adresli: Evet

Özet

The binding of a series pyridylbutynylamines 6 was examined at alpha4beta2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models. (C) 2003 Elsevier Ltd. All rights reserved.