Caffeic Acid Phenethyl Ester: Its Protective Role Against Certain Major Eye Diseases

Akyol S., Ugurcu V., Balci M., Gurel A., Erden G., Cakmak O., ...More

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, vol.30, no.9, pp.700-708, 2014 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 30 Issue: 9
  • Publication Date: 2014
  • Doi Number: 10.1089/jop.2014.0046
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.700-708


As an effective compound found mainly in the honeybee product propolis, caffeic acid phenethyl ester (CAPE) has been commonly utilized as a medicine and remedial agent, in a number of countries. Specifically, it might inhibit nuclear factor kappa B at micromolar concentrations and demonstrate antioxidant, antineoplastic, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and anti-inflammatory features. This review article summarizes the recent progress regarding the favorable effects of CAPE on a number of eye disease models, including cataract and posterior capsule opacification, corneal diseases, retina and optic nerve-related diseases, ischemia/reperfusion injury of retina, inflammation and infection-related diseases. CAPE has been found to exhibit promising efficacy, with minimal adverse effects, in animal and cell culture studies of several eye diseases.