Caffeic Acid Phenethyl Ester: Its Protective Role Against Certain Major Eye Diseases


Akyol S., Ugurcu V., Balci M., Gurel A., Erden G., Cakmak O., ...Daha Fazla

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, cilt.30, sa.9, ss.700-708, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 30 Konu: 9
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1089/jop.2014.0046
  • Dergi Adı: JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
  • Sayfa Sayıları: ss.700-708

Özet

As an effective compound found mainly in the honeybee product propolis, caffeic acid phenethyl ester (CAPE) has been commonly utilized as a medicine and remedial agent, in a number of countries. Specifically, it might inhibit nuclear factor kappa B at micromolar concentrations and demonstrate antioxidant, antineoplastic, antiproliferative, cytostatic, antiviral, antibacterial, antifungal, and anti-inflammatory features. This review article summarizes the recent progress regarding the favorable effects of CAPE on a number of eye disease models, including cataract and posterior capsule opacification, corneal diseases, retina and optic nerve-related diseases, ischemia/reperfusion injury of retina, inflammation and infection-related diseases. CAPE has been found to exhibit promising efficacy, with minimal adverse effects, in animal and cell culture studies of several eye diseases.