Oxidative stress gene polymorphisms may have an impact in the development of ischemic stroke


KARAHALİL B., ELKAMA A., Orhan G.

JOURNAL OF GENE MEDICINE, vol.19, no.3, 2017 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1002/jgm.2947
  • Journal Name: JOURNAL OF GENE MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: catalase, glutathione peroxidase 1, ischemic stroke, manganese superoxide dismutase, oxidative stress genes, polymerase chain reaction, SUPEROXIDE-DISMUTASE, GPX ACTIVITY, ASSOCIATION, CATALASE, RISK, GLUTATHIONE-PEROXIDASE-1, ENZYMES, SMOKING, MNSOD

Abstract

Background Antioxidants are responsible for detoxification of harmful effects of reactive oxygen species. Genetic factors may influence antioxidant activity as a result of polymorphisms on antioxidant enzymes. These polymorphisms can be risk in ischemic stroke (IS) risk. IS is a disorder with genetic and environmental factors contributing to overall risk. Although a few studies have been conducted, there have been no reports on catalase (CAT C262T), manganese superoxide dismutase (MnSOD Ala16Val) and glutathione peroxidase 1 (GPX1 Pro198Leu) gene polymorphisms and IS risk.