Oxidative stress gene polymorphisms may have an impact in the development of ischemic stroke

KARAHALİL B. , ELKAMA A. , Orhan G.

JOURNAL OF GENE MEDICINE, vol.19, no.3, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.1002/jgm.2947
  • Title of Journal : JOURNAL OF GENE MEDICINE

Abstract

Background Antioxidants are responsible for detoxification of harmful effects of reactive oxygen species. Genetic factors may influence antioxidant activity as a result of polymorphisms on antioxidant enzymes. These polymorphisms can be risk in ischemic stroke (IS) risk. IS is a disorder with genetic and environmental factors contributing to overall risk. Although a few studies have been conducted, there have been no reports on catalase (CAT C262T), manganese superoxide dismutase (MnSOD Ala16Val) and glutathione peroxidase 1 (GPX1 Pro198Leu) gene polymorphisms and IS risk.