Oxidative stress gene polymorphisms may have an impact in the development of ischemic stroke

KARAHALİL B., ELKAMA A., Orhan G.

JOURNAL OF GENE MEDICINE, cilt.19, sa.3, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/jgm.2947
  • Dergi Adı: JOURNAL OF GENE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: catalase, glutathione peroxidase 1, ischemic stroke, manganese superoxide dismutase, oxidative stress genes, polymerase chain reaction, SUPEROXIDE-DISMUTASE, GPX ACTIVITY, ASSOCIATION, CATALASE, RISK, GLUTATHIONE-PEROXIDASE-1, ENZYMES, SMOKING, MNSOD
  • Gazi Üniversitesi Adresli: Evet

Özet

Background Antioxidants are responsible for detoxification of harmful effects of reactive oxygen species. Genetic factors may influence antioxidant activity as a result of polymorphisms on antioxidant enzymes. These polymorphisms can be risk in ischemic stroke (IS) risk. IS is a disorder with genetic and environmental factors contributing to overall risk. Although a few studies have been conducted, there have been no reports on catalase (CAT C262T), manganese superoxide dismutase (MnSOD Ala16Val) and glutathione peroxidase 1 (GPX1 Pro198Leu) gene polymorphisms and IS risk.