Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study

ŞİŞMANLAR EYÜBOĞLU T., ASLAN A. T., RAMASLI GÜRSOY T., PEKCAN S., KÖSE M., HANGÜL M., ...Daha Fazla

EUROPEAN JOURNAL OF PEDIATRICS, cilt.181, sa.8, ss.3093-3101, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 181 Sayı: 8
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s00431-022-04528-2
  • Dergi Adı: EUROPEAN JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.3093-3101
  • Anahtar Kelimeler: Caspase-1, Children, IL-18, Post infectious bronchiolitis obliterans, BINDING-PROTEIN, AIRWAY INFLAMMATION, NLRP3 INFLAMMASOME, IL-18, SERUM, TH1, CYTOKINE, DISEASE, SARCOIDOSIS, FIBROSIS
  • Gazi Üniversitesi Adresli: Evet

Özet

The exact immunological mechanisms of post infectious bronchiolitis obliterans (PIBO) in childhood are not fully known. It has been shown that the inflammasome and IL-18 pathway play important roles in the pathogenesis of lung fibrosis. We aimed to investigate the role of caspase-1, IL-18, and IL-18 components in PIBO. From January to May 2020, children with PIBO, children with history of influenza infection without PIBO, and healthy children were asked to participate in the study in three pediatric pulmonology centers. Serum caspase-1, IL-18, IL-18BP, IL-18R, and INF-gamma levels were measured by ELISA and compared between the 3 groups. There were 21 children in the PIBO group, 16 children in the influenza group, and 39 children in the healthy control group. No differences in terms of age and gender between the 3 groups were found. IL-18 and IL-18BP levels were higher in the healthy control group (p = 0.018, p = 0.005, respectively). IL- 18R was higher in the PIBO group (p = 0.001) and caspase-1 was higher in the PIBO and influenza group than the healthy control group (p = 0.002). IFN-gamma levels did not differ between the 3 groups. IL-18BP/IL-18 was higher in the influenza group than the PIBO group and the healthy control group (p = 0.003).