Akademik Veri Yönetim Sistemi
37th European Congress of Pathology, Vienna, Avusturya, 6 - 10 Eylül 2025, cilt.487, ss.1-563, (Özet Bildiri)
E-PS-13-054
Tumours metastasizing to the jawbones, oral cavity and salivary glands: a retrospective study
A.H. Üstündağ¹, İ. Atak Seçen¹, B. Öğüt², B. Toközlü¹
¹Gazi University, Department of Oral Pathology, Ankara, Turkey, ²Gazi University, Department of Pathology, Ankara, Turkey
Background & Objectives: Distant metastasis to the oral cavity is rare, comprising approximately 1–1.5% of all oral malignancies. The most frequent primary sites are the breast and lung, with a jawbone-tosoft tissue ratio of 2:1. The study aims to evaluate the clinicopathological features of tumours metastasizing to the jaw bones, salivary glands and soft tissues of the oral cavity in the Central Anatolia region.
Methods: This study is a retrospective analysis spanning 25 years, covering the period from January 2000 to January 2025. Clinicopathological data were obtained from electronic medical records.
Results: A total of 43 cases (28 males, 15 females; M:F ratio 1.75:1) with a mean age of 60 years (range 25–85) were analysed. Metastases were located in the oral soft tissue (67%), salivary glands (28%), and jawbone (5%). Adenocarcinomas were the most common metastatic tumours (44%), primarily from the lung, gastrointestinal tract, colon, oesophagus, and prostate. Other tumour types included lymphomas (11%), squamous cell carcinoma/malignant epithelial tumour (9%), renal cell carcinoma, malignant melanoma, sebaceous carcinoma, and myeloid sarcoma (each 5%), and various others (16%). Adenocarcinoma and sebaceous carcinoma metastases were more frequent in males, while all malignant melanoma cases occurred in females. Survival data were available for 30 patients: 12 were alive, and 18 had died at the time of analysis.
Conclusion: Metastasis to the oral cavity is a rare occurrence and is characterized by a poor prognosis. Any lesion found in the oral cavity should undergo biopsy and thorough evaluation, as metastatic tumours can mimic benign conditions clinically. The challenging diagnosis requires a multidisciplinary approach. Oral and maxillofacial pathologists play a vital role in the early detection of oral cancers and in recognizing metastatic lesions affecting the maxillofacial region.