Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage

Belen D., Besalti O., Yigitkanli K., Koesemehmetoglu K., Simsek S., Bolay H. B.

ACTA NEUROCHIRURGICA, cilt.149, sa.10, ss.1041-1047, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 149 Sayı: 10
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00701-007-1275-1
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1041-1047
  • Anahtar Kelimeler: animal studies, cerebral vasospasm, leflunomide, subarachnoid haemorrhage, MAJOR CEREBRAL-ARTERIES, CHRONIC CEREBROVASOSPASM, RHEUMATOID-ARTHRITIS, BARRIER DISRUPTION, ANALOG FK778, TIME-COURSE, IN-VITRO, MODEL, ANGIOGENESIS, INHIBITION
  • Gazi Üniversitesi Adresli: Evet

Özet

Background. Though cerebral vasospasm is one of the most serious complications of subarachnoid haemorrhage (SAH), its complex pathogenesis is poorly understood and available clinical treatment options are unsatisfactory. This study was designed to examine the efficacy of leflunomide, an immunomodulatory agent with inhibitory properties, on vascular smooth muscle cell proliferation and inflammation in a rabbit cerebral vasospasm model.