Leflunomide prevents vasospasm secondary to subarachnoid haemorrhage


Belen D., Besalti O., Yigitkanli K., Koesemehmetoglu K., Simsek S., Bolay H. B.

ACTA NEUROCHIRURGICA, cilt.149, sa.10, ss.1041-1047, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 149 Konu: 10
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00701-007-1275-1
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Sayfa Sayıları: ss.1041-1047

Özet

Background. Though cerebral vasospasm is one of the most serious complications of subarachnoid haemorrhage (SAH), its complex pathogenesis is poorly understood and available clinical treatment options are unsatisfactory. This study was designed to examine the efficacy of leflunomide, an immunomodulatory agent with inhibitory properties, on vascular smooth muscle cell proliferation and inflammation in a rabbit cerebral vasospasm model.