Plerixafor use in patients with previous mobilization failure: A multicenter experience

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Tekgunduz E., ALTUNTAŞ F., Sivgin S., Aki S. Z., DÖNMEZ A., TOPÇUOĞLU P., ...More

TRANSFUSION AND APHERESIS SCIENCE, vol.47, no.1, pp.77-80, 2012 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 47 Issue: 1
• Publication Date: 2012
• Doi Number: 10.1016/j.transci.2012.05.004
• Journal Name: TRANSFUSION AND APHERESIS SCIENCE
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.77-80
• Gazi University Affiliated: Yes

Abstract

Plerixafor in conjunction with G-CSF (G-P) is an effective strategy for hematopoietic stem cell mobilization in patients with previously failed mobilization attempt. Here we report our results with G-P among patients with at least one mobilization failure with G-CSF alone (G) or G-CSF plus chemotherapy (G-C). The study included 20 consecutive patients with lymphoma and myeloma from five centers. In 14 (70%) patients, a minimum of 2 x 10(6)/kg CD34+ stem cells were collected and 16 out of 20 patients (80%) were able to proceed to ASCT. Our study indicates that plerixafor can safely rescue patients with a history of mobilization failure. (C) 2012 Elsevier Ltd. All rights reserved.