Plerixafor use in patients with previous mobilization failure: A multicenter experience


Tekgunduz E., ALTUNTAŞ F., Sivgin S., Aki S. Z. , DÖNMEZ A., TOPÇUOĞLU P., ...More

TRANSFUSION AND APHERESIS SCIENCE, vol.47, no.1, pp.77-80, 2012 (SCI-Expanded) identifier identifier identifier

Abstract

Plerixafor in conjunction with G-CSF (G-P) is an effective strategy for hematopoietic stem cell mobilization in patients with previously failed mobilization attempt. Here we report our results with G-P among patients with at least one mobilization failure with G-CSF alone (G) or G-CSF plus chemotherapy (G-C). The study included 20 consecutive patients with lymphoma and myeloma from five centers. In 14 (70%) patients, a minimum of 2 x 10(6)/kg CD34+ stem cells were collected and 16 out of 20 patients (80%) were able to proceed to ASCT. Our study indicates that plerixafor can safely rescue patients with a history of mobilization failure. (C) 2012 Elsevier Ltd. All rights reserved.