Plerixafor use in patients with previous mobilization failure: A multicenter experience


Tekgunduz E., ALTUNTAŞ F., Sivgin S., Aki S. Z. , DÖNMEZ A., TOPÇUOĞLU P., ...Daha Fazla

TRANSFUSION AND APHERESIS SCIENCE, cilt.47, sa.1, ss.77-80, 2012 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Konu: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.transci.2012.05.004
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Sayfa Sayıları: ss.77-80

Özet

Plerixafor in conjunction with G-CSF (G-P) is an effective strategy for hematopoietic stem cell mobilization in patients with previously failed mobilization attempt. Here we report our results with G-P among patients with at least one mobilization failure with G-CSF alone (G) or G-CSF plus chemotherapy (G-C). The study included 20 consecutive patients with lymphoma and myeloma from five centers. In 14 (70%) patients, a minimum of 2 x 10(6)/kg CD34+ stem cells were collected and 16 out of 20 patients (80%) were able to proceed to ASCT. Our study indicates that plerixafor can safely rescue patients with a history of mobilization failure. (C) 2012 Elsevier Ltd. All rights reserved.