THE EFFECTS OF ENDOTHELIN PEPTIDES IN THE RABBIT ISOLATED-PERFUSED KIDNEY


ERCAN Z., TURKER R., ULUOGLU C., YAZAR O., ZENGIL H.

GENERAL PHARMACOLOGY, vol.25, no.7, pp.1471-1476, 1994 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 7
  • Publication Date: 1994
  • Doi Number: 10.1016/0306-3623(94)90176-7
  • Title of Journal : GENERAL PHARMACOLOGY
  • Page Numbers: pp.1471-1476

Abstract

1. Endothelin-1 (21-amino acids) and pre-pro endothelin-1 (39-amino acids) produced a concentration-dependent increase in perfusion pressure when infused through the renal artery of rabbit isolated perfused kidney. Addition of phosphoramidon to the medium caused a potentiation in the vasoconstrictor response to endothelin-1 and greatly, but not completely, inhibited vasoconstriction induced by pre-pro-endothelin-1.