THE EFFECTS OF ENDOTHELIN PEPTIDES IN THE RABBIT ISOLATED-PERFUSED KIDNEY
GENERAL PHARMACOLOGY, cilt.25, sa.7, ss.1471-1476, 1994 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 7
- Basım Tarihi: 1994
- Doi Numarası: 10.1016/0306-3623(94)90176-7
- Dergi Adı: GENERAL PHARMACOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1471-1476
- Gazi Üniversitesi Adresli: Hayır
Özet
1. Endothelin-1 (21-amino acids) and pre-pro endothelin-1 (39-amino acids) produced a concentration-dependent increase in perfusion pressure when infused through the renal artery of rabbit isolated perfused kidney. Addition of phosphoramidon to the medium caused a potentiation in the vasoconstrictor response to endothelin-1 and greatly, but not completely, inhibited vasoconstriction induced by pre-pro-endothelin-1.