The genomic road to invasion-examining the similarities and differences in the genomes of associated oral pre-cancer and cancer samples


Creative Commons License

Wood H. M. , Daly C., Chalkley R., Senguven B., Ross L., Egan P., ...More

GENOME MEDICINE, vol.9, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2017
  • Doi Number: 10.1186/s13073-017-0442-0
  • Title of Journal : GENOME MEDICINE

Abstract

Background: It is frequently assumed that pre-invasive lesions are simpler precursors of cancer and will contain a limited subset of the genomic changes seen in their associated invasive disease. Driver mutations are thought to occur early, but it is not known how many of these are present in pre-invasive lesions. These assumptions need to be tested with the increasing focus on both personalised cancer treatments and early detection methodologies.