GENOME MEDICINE, vol.9, 2017 (SCI-Expanded)
Article / Article
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Pre-cancer, Oral cancer, Tumour progression, SQUAMOUS-CELL CARCINOMA, MALIGNANT-TRANSFORMATION, GENETIC PROGRESSION, DYSPLASIA, ARCHITECTURE, INFORMATION, EVOLUTION, HEAD, DNA
Gazi University Affiliated:
Background: It is frequently assumed that pre-invasive lesions are simpler precursors of cancer and will contain a limited subset of the genomic changes seen in their associated invasive disease. Driver mutations are thought to occur early, but it is not known how many of these are present in pre-invasive lesions. These assumptions need to be tested with the increasing focus on both personalised cancer treatments and early detection methodologies.