The genomic road to invasion-examining the similarities and differences in the genomes of associated oral pre-cancer and cancer samples

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Wood H. M., Daly C., Chalkley R., Senguven B., Ross L., Egan P., ...Daha Fazla

GENOME MEDICINE, cilt.9, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1186/s13073-017-0442-0
  • Dergi Adı: GENOME MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Pre-cancer, Oral cancer, Tumour progression, SQUAMOUS-CELL CARCINOMA, MALIGNANT-TRANSFORMATION, GENETIC PROGRESSION, DYSPLASIA, ARCHITECTURE, INFORMATION, EVOLUTION, HEAD, DNA
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: It is frequently assumed that pre-invasive lesions are simpler precursors of cancer and will contain a limited subset of the genomic changes seen in their associated invasive disease. Driver mutations are thought to occur early, but it is not known how many of these are present in pre-invasive lesions. These assumptions need to be tested with the increasing focus on both personalised cancer treatments and early detection methodologies.