Methyl parathion induced nephrotoxicity in male rats and protective role of vitamins C and E

KALENDER S., KALENDER Y., Durak D., Ogutcu A., Uzurthisarcikli M., Cevrimli B. S., ...Daha Fazla

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, cilt.88, sa.2, ss.213-218, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.pestbp.2006.11.007
  • Dergi Adı: PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.213-218
  • Anahtar Kelimeler: organophosphate insecticide, methyl parathion, vitamin E, vitamin C, nephrotoxicity, malondialdehyde, histopathology, ORGANOPHOSPHATE INSECTICIDE METHIDATHION, INDUCED OXIDATIVE STRESS, FREE-RADICAL METABOLISM, VASCULAR WALL DAMAGE, INDUCED CARDIOTOXICITY, ANTIOXIDANT ENZYMES, LIPID-PEROXIDATION, TOXICITY, DIAZINON, ERYTHROCYTES
  • Gazi Üniversitesi Adresli: Evet

Özet

Methyl parathion is an organophosphate insecticide that has been used in agriculture and domestic for several years. Vitamin C (200 mg/kg bw per day) + vitamin E (200 mg/kg bw per clay), methyl parathion (0.28 mg/kg bw per day) and vitamin C (200 mg/kg bw per day) + vitamin E (200 mg/kg bw per day) + methyl parathion (0.28 mg/kg bw per day) combination were given to rats orally via gavage for 7 weeks. Body and kidney weights, malondialdehyde (MDA) levels and histopathological changes were investigated at the end of 4th and 7th weeks comparatively with control group. When methyl parathion-treated group and vitamins C and E + methyl parathion-treated group were compared to control group body and kidney weights decreased significantly at the end of 4th and 7th weeks. MDA levels increased in kidney tissues of the methyl parathion- and vitamins C and E + methyl parathion-treated groups compared to control group. MDA levels decreased significantly in vitamins C and E + methyl parathion treated group compared with methyl parathion treated group at the end of 4th and 7th weeks. In our light microscopic investigations, after 4 weeks of methyl parathion exposure, glomerular atrophy and vascular dilatation, and after 7 weeks, necrosis and edema were observed in the kidney tissues. After 4 weeks of vitamins C and E + methyl parathion exposure, mononuclear cell infiltrations, and after 7 weeks, calcification were detected in the kidney tissues. (c) 2006 Elsevier Inc. All rights reserved.