The emerging importance of cortical spreading depression in migraine headache

Bolay H. B. , Moskowitz M.

Revue Neurologique, vol.161, pp.655-657, 2005 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Abstract
  • Volume: 161
  • Publication Date: 2005
  • Doi Number: 10.1016/s0035-3787(05)85108-2
  • Journal Name: Revue Neurologique
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.655-657


Migraine is a disabling neurovascular disorder with a complex pathophysiology. Functional imaging and magneto encephalographic studies strongly suggest that Cortical Spreading Depression (CSD) constitutes the biological basis for the neurologic aura that precedes headache in one fourth of migrainers. It is likely that the aura is the generator of the headache since experimentally, CSD triggers the activation of the trigeminovascular system, possibly through matrix metalloproteases activation which is associated with an increase in vascular permeability. These data may have therapeutic implications: strategies to block trigeminal activation or its downstream consequences are central to treat the acute headache whereas strategies to block events lying upstream of trigeminal activation would be crucial in prophylaxis. © Masson.