Hepatic failure due to CD3+plasma cell infiltration of the liver in multiple myeloma

Yagci M., Sucak G., Akyol G., Haznedar R.

ACTA HAEMATOLOGICA, vol.107, no.1, pp.38-42, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 107 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1159/000046628
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.38-42
  • Keywords: multiple myeloma, liver failure, T cell antigen, LIGHT-CHAIN DEPOSITION, AMYLOIDOSIS, DISEASE
  • Gazi University Affiliated: Yes


We present a case of multiple myeloma who died of liver failure 7.5 months after initial diagnosis. Postmortem liver biopsy revealed diffuse CD3-expressing plasma cell infiltration and eosinophilic amorphous material deposition which was considered as light chain deposits. T cell receptor-gamma rearrangement was not detected in liver biopsy sections using the polymerase chain reaction despite CD3 positivity. To our knowledge, this is the first report of CM-expressing plasma cell infiltration in tissue sections. The discordance between the, phenotype and the genotype suggests a partial activation of genes encoding the T cell antigens by the transforming event. We also concluded that CD3 positivity was associated with short survival, which is consistent with previous data. Copyright (C) 2002 S. Karger AG, Basel.