DOES PGE(2) ACT AS A MEDIATOR FOR ENDOTHELIN RELEASE


AKTAN A., BUYUKGEBIZ O., YEGEN Ş. C. , YALCIN S., HAKLAR G., YALIN R., ...Daha Fazla

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.50, sa.1, ss.37-41, 1994 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Konu: 1
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0952-3278(94)90103-1
  • Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
  • Sayfa Sayıları: ss.37-41

Özet

To investigate the effect of iloprost (ZK 36374) and thromboxane synthetase inhibitor UK 38485 on endothelin release by the intestinal vascular endothelium after ischemia/reperfusion (IR) injury, five experimental groups were formed. The groups consisted of sham, control, iloprost treated (ILO), UK 38485 treated (TSI), and iloprost + UK 38485 treated (ILO + TSI) groups. The last three groups received the corresponding agents and then the superior mesenteric artery was clamped for 30 min followed by 90 min reperfusion. Endothelin levels in the portal blood and malondialdehyde (MDA), prostaglandin E(2) (PGE(2)) and leukotriene C-4 (LTC(4)) levels in the intestinal tissue were determined.