Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal)hydrazone derivatives

Gokce M., UTKU S., Kupeli E.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.44, no.9, pp.3760-3764, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 9
  • Publication Date: 2009
  • Doi Number: 10.1016/j.ejmech.2009.04.048
  • Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3760-3764
  • Keywords: Pyridazinone, Benzal hydrazone, Analgesic, Anti-inflammatory activity, ANTINOCICEPTIVE AGENTS, MANNICH-BASES, ANALOGS, POTENT, MECHANISM
  • Gazi University Affiliated: Yes

Abstract

In this study new 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted benzal)hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents. The structures of compounds were elucidated by spectral and elemental analysis. Compounds Va, Vb and Vc were exhibited more potent analgesic activity than ASA. Also these derivatives demonstrated anti-inflammatory activity as well as standard compound indomethacin. Side effects of the compounds were examined on gastric mucosa. None of the compounds showed gastric ulcerogenic effect compared with reference nonsteroidal anti-inflammatory drugs (NSAIDs). On the basis of available data, the structure-activity relationship of V derivatives was also discussed. (C) 2009 Elsevier Masson SAS. All rights reserved.