Synthesis and antinociceptive activity of (2-benzazolon-3-yl)propionamide derivatives

Onkol T., Ito S., Yildirim E., Erol K., Sahin M.

ARCHIV DER PHARMAZIE, cilt.334, sa.1, ss.17-20, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 334 Sayı: 1
  • Basım Tarihi: 2001
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.17-20
  • Gazi Üniversitesi Adresli: Hayır

Özet

The syntheses of (2-benzothiazolinon-3-yl)propionamide and (2-benzoxazolinon-3-yl)propionamide derivatives are reported. The structures of these compounds are elucidated by their IR and H-1-NMR spectral data, as well as by elemental analysis. The compounds were tested for antinociceptive activity by hot plate, tail flick, tail clip, and modified Koster tests. Compounds 6b and 7d were found to be the most promising compounds among the substances investigated.