Antimicrobial Activity of Flavonoids against Extended-Spectrum beta-Lactamase (ES beta L)-Producing Klebsiella pneumoniae

Oezcelik B., Orhan D. D., Oezgen S., Ergun F.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, vol.7, no.4, pp.1151-1157, 2008 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 4
  • Publication Date: 2008
  • Journal Name: TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, International Pharmaceutical Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1151-1157
  • Keywords: Antimicrobial activity, ES beta Ls, Flavonoids, Klebsiella pneumoniae, Ofloxacin, Ampicillin, VISCUM-ALBUM, GLYCOSIDES, ESBL
  • Gazi University Affiliated: Yes

Abstract

Purpose: In the present study, six flavonoids (5,7-dimethoxyflavanone-4'-O-beta-D-glucopyranoside, 5,7-dimethoxyflavanone- 4'-O-[2 ''-O-(5'''-O-trans-cinnamoyl)-beta-D-apiofuranosyl]-beta-D-glucopyranoside, naringenin-7-O-beta-D-glucopyranoside, 5,7,3'-trihydroxy-flavanone-4'-O-beta-D-glucopyranoside, rutin, and nicotiflorin) isolated from Galium fissurense, Viscum album ssp. album and Cirsium hypoleucum were screened against extended-spectrum beta-lactamase producing multidrug-resistant (trimetoprime-sulphametoxazole, sulbactam-ampicillin, clavulonate-amoxicilin, ceftriaxon, cefepime, imipenem, ceftazidime, tobramicin, gentamicin, ofloxacin, ciprofloxacin) bacteria Klebsiella pneumoniae (ES beta Ls).