Antimicrobial Activity of Flavonoids against Extended-Spectrum beta-Lactamase (ES beta L)-Producing Klebsiella pneumoniae


Oezcelik B., Orhan D. D. , Oezgen S., Ergun F.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, cilt.7, sa.4, ss.1151-1157, 2008 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Konu: 4
  • Basım Tarihi: 2008
  • Dergi Adı: TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
  • Sayfa Sayıları: ss.1151-1157

Özet

Purpose: In the present study, six flavonoids (5,7-dimethoxyflavanone-4'-O-beta-D-glucopyranoside, 5,7-dimethoxyflavanone- 4'-O-[2 ''-O-(5'''-O-trans-cinnamoyl)-beta-D-apiofuranosyl]-beta-D-glucopyranoside, naringenin-7-O-beta-D-glucopyranoside, 5,7,3'-trihydroxy-flavanone-4'-O-beta-D-glucopyranoside, rutin, and nicotiflorin) isolated from Galium fissurense, Viscum album ssp. album and Cirsium hypoleucum were screened against extended-spectrum beta-lactamase producing multidrug-resistant (trimetoprime-sulphametoxazole, sulbactam-ampicillin, clavulonate-amoxicilin, ceftriaxon, cefepime, imipenem, ceftazidime, tobramicin, gentamicin, ofloxacin, ciprofloxacin) bacteria Klebsiella pneumoniae (ES beta Ls).