Ultrastructure protection and attenuation of lipid peroxidation after blockade of presynaptic release of glutamate by lamotrigine in experimental spinal cord injury


Tufan K., Oztanir N., Ofluoglu E., Ozogul C., Uzum N., DURSUN A., ...More

NEUROSURGICAL FOCUS, vol.25, no.5, 2008 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.3171/foc.2008.25.11.e6
  • Journal Name: NEUROSURGICAL FOCUS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: electron microscopy, experimental spinal cord injury, lamotrigine, lipid peroxidation, rat, spinal cord ultrastructure, FOCAL ISCHEMIA, AMINO-ACIDS, RECEPTORS, RATS, MECHANISM, SODIUM, BLOOD, NMDA

Abstract

Object. Lamotrigine is an antiepileptic drug that inhibits presynaptic voltage-gated sodium channels and reduces the presynaptic release of glutamate in pathological states. Neuroprotective effects of this drug have already been demonstrated in cerebral ischemia models. The aim of the present study was to determine the effects of presynaptic glutamate release inhibition on experimental spinal cord injury (SCI).