NEUROSURGICAL FOCUS, vol.25, no.5, 2008 (Peer-Reviewed Journal)
Article / Article
Science Citation Index Expanded, Scopus
electron microscopy, experimental spinal cord injury, lamotrigine, lipid peroxidation, rat, spinal cord ultrastructure, FOCAL ISCHEMIA, AMINO-ACIDS, RECEPTORS, RATS, MECHANISM, SODIUM, BLOOD, NMDA
Object. Lamotrigine is an antiepileptic drug that inhibits presynaptic voltage-gated sodium channels and reduces the presynaptic release of glutamate in pathological states. Neuroprotective effects of this drug have already been demonstrated in cerebral ischemia models. The aim of the present study was to determine the effects of presynaptic glutamate release inhibition on experimental spinal cord injury (SCI).